4g1p: Difference between revisions
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{{STRUCTURE_4g1p| PDB=4g1p | SCENE= }} | |||
===Structural and Mechanistic Basis of Substrate Recognition by Novel Di-peptidase Dug1p From Saccharomyces cerevisiae=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DUG1_YEAST DUG1_YEAST]] Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides.<ref>PMID:17179087</ref> <ref>PMID:19346245</ref> | |||
==About this Structure== | |||
[[4g1p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G1P OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Saccharomyces cerevisiae s288c]] | |||
[[Category: Kumaran, S.]] | |||
[[Category: Mittal, M.]] | |||
[[Category: Pandya, V K.]] | |||
[[Category: Singh, A K.]] | |||
[[Category: Singh, M.]] | |||
[[Category: Singh, V.]] | |||
[[Category: Alpha/beta scaffold]] | |||
[[Category: Di-nuclear peptidase]] | |||
[[Category: Hydrolase]] | |||
[[Category: M20 family metallo-peptidase]] | |||
[[Category: N-terminal catalytic domain/c-terminal lid domain]] | |||
Revision as of 05:03, 18 July 2013
Structural and Mechanistic Basis of Substrate Recognition by Novel Di-peptidase Dug1p From Saccharomyces cerevisiae
Function
[DUG1_YEAST] Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Functions also in a DUG2-DUG3-independent manner as a dipeptidase with high specificity for Cys-Gly and no activity toward tri- or tetrapeptides.[1] [2]
About this Structure
4g1p is a 1 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.
Reference
- ↑ Ganguli D, Kumar C, Bachhawat AK. The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae. Genetics. 2007 Mar;175(3):1137-51. Epub 2006 Dec 18. PMID:17179087 doi:10.1534/genetics.106.066944
- ↑ Kaur H, Kumar C, Junot C, Toledano MB, Bachhawat AK. Dug1p Is a Cys-Gly peptidase of the gamma-glutamyl cycle of Saccharomyces cerevisiae and represents a novel family of Cys-Gly peptidases. J Biol Chem. 2009 May 22;284(21):14493-502. doi: 10.1074/jbc.M808952200. Epub, 2009 Apr 3. PMID:19346245 doi:10.1074/jbc.M808952200
