3u4i: Difference between revisions
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{{STRUCTURE_3u4i| PDB=3u4i | SCENE= }} | {{STRUCTURE_3u4i| PDB=3u4i | SCENE= }} | ||
===CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template=== | ===CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template=== | ||
{{ABSTRACT_PUBMED_23840430}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/CD38_HUMAN CD38_HUMAN]] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. | |||
==About this Structure== | ==About this Structure== | ||
[[3u4i]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U4I OCA]. | [[3u4i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U4I OCA]. | ||
==See Also== | |||
*[[Cluster of Differentiation CD38|Cluster of Differentiation CD38]] | |||
==Reference== | |||
<ref group="xtra">PMID:023840430</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Graeff, R.]] | [[Category: Graeff, R.]] | ||
[[Category: Hao, Q.]] | [[Category: Hao, Q.]] | ||
Revision as of 11:17, 24 July 2013
CD38 structure-based inhibitor design using the N1-cyclic inosine 5'-diphosphate ribose template
Template:ABSTRACT PUBMED 23840430
Function
[CD38_HUMAN] Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.
About this Structure
3u4i is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Moreau C, Liu Q, Graeff R, Wagner GK, Thomas MP, Swarbrick JM, Shuto S, Lee HC, Hao Q, Potter BV. CD38 Structure-Based Inhibitor Design Using the 1-Cyclic Inosine 5'-Diphosphate Ribose Template. PLoS One. 2013 Jun 19;8(6):e66247. Print 2013. PMID:23840430 doi:10.1371/journal.pone.0066247
