1uzz

File:1uzz.gif

spinqualitylabelsall models 1uzz, resolution 2.13Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D

ERYTHRINA CRISTAGALLI BOUND TO N-LINKED OLIGOSACCHARIDE AND LACTOSE

Overview

Erythrina cristagalli lectin (ECL) is a galactose-specific legume lectin., Although its biological function in the legume is unknown, ECL exhibits, hemagglutinating activity in vitro and is mitogenic for T lymphocytes. In, addition, it has been recently shown that ECL forms a novel conjugate when, coupled to a catalytically active derivative of the type A neurotoxin from, Clostridium botulinum, thus providing a therapeutic potential. ECL is, biologically active as a dimer in which each protomer contains a, functional carbohydrate-combining site. The crystal structure of native, ECL was recently reported in complex with lactose and 2'-fucosyllactose., ECL protomers adopt the legume lectin fold but form non-canonical dimers, via the handshake motif as was previously observed for Erythrina, ... [(full description)]

About this Structure

1UZZ is a [Single protein] structure of sequence from [Eukaryota] with CA, MN and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

Reference

Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose., Turton K, Natesh R, Thiyagarajan N, Chaddock JA, Acharya KR, Glycobiology. 2004 Oct;14(10):923-9. Epub 2004 Jun 16. PMID:15201215

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