2xjh: Difference between revisions

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[[Image:2xjh.png|left|200px]]
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{{STRUCTURE_2xjh|  PDB=2xjh  |  SCENE=  }}  
{{STRUCTURE_2xjh|  PDB=2xjh  |  SCENE=  }}  
===Structure and Copper-binding Properties of Methanobactins from Methylosinus trichosporium OB3b===
===Structure and Copper-binding Properties of Methanobactins from Methylosinus trichosporium OB3b===
{{ABSTRACT_PUBMED_21254756}}


 
==Function==
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[[http://www.uniprot.org/uniprot/MBCTN_METTR MBCTN_METTR]] Chalkophore involved in scavenging, uptake and suppression of toxicity of copper. Each apo-methanobactin (apo-mb) complexes 1 Cu(2+) or Cu(1+) ion to form Cu(1+)-mb (Cu-mb) which is then taken up by the cell. Enhances growth rate in the presence of copper and reduces growth lag upon exposition to elevated levels of copper. Cu-mb contributes to the switchover from soluble methane monooxygenase (sMMO) to the membrane-bound particulate MMO (pMMO) by inducing transcription of pMMO subunit A. It also stimulates the enzymatic activity of pMMO. In the absence of copper, binds other metal ions, like Zn(2+), Ag(1+), Au(3+), Co(2+), Cd(2+), Fe(3+), Hg(2+), Mn(2+), Ni(2+), Pb(2+) or U(6+), but not Ba(2+), Ca(2+), La(2+), Mg(2+) or Sr(2+). Uptake is an active process, which may involve TonB-dependent transporters, and as such does not involve porins. Cu-Mb can be taken up by other methanotrophic bacteria but not by E.coli. Has Cu-dependent superoxide dismutase-like activity. Shows reductant-dependent oxidase and hydrogen peroxide reductase activities. Reduces copper-levels in liver in a rat model of Wilson disease.<ref>PMID:15361623</ref> <ref>PMID:15794651</ref> <ref>PMID:16332035</ref> <ref>PMID:16207923</ref> <ref>PMID:16445286</ref> <ref>PMID:17070918</ref> <ref>PMID:17615240</ref> <ref>PMID:18372044</ref> <ref>PMID:20961038</ref> <ref>PMID:20817303</ref> <ref>PMID:21254756</ref> <ref>PMID:21900235</ref> <ref>PMID:21242075</ref> 
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{{ABSTRACT_PUBMED_21254756}}


==About this Structure==
==About this Structure==
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==Reference==
==Reference==
<ref group="xtra">PMID:021254756</ref><ref group="xtra">PMID:015361623</ref><ref group="xtra">PMID:018729522</ref><references group="xtra"/>
<ref group="xtra">PMID:021254756</ref><references group="xtra"/><references/>
[[Category: Methylosinus trichosporium]]
[[Category: Methylosinus trichosporium]]
[[Category: Basle, A.]]
[[Category: Basle, A.]]
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