2dpr: Difference between revisions

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{{Seed}}
[[Image:2dpr.png|left|200px]]
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{{STRUCTURE_2dpr|  PDB=2dpr  |  SCENE=  }}  
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===The crystal structures of the calcium-bound con-G and con-T(K7Glu) dimeric peptides demonstrate a novel metal-dependent helix-forming motif===
{{ABSTRACT_PUBMED_17243678}}


===The crystal structures of the calcium-bound con-G and con-T(K7Gla) dimeric peptides demonstrate a novel metal-dependent helix-forming motif===
==Function==
 
[[http://www.uniprot.org/uniprot/CKT_CONTU CKT_CONTU]] Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin inhibits both NR2A and NR2B subunits of N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons. Induces sleep-like symptoms in young mice and hyperactivity in older mice.<ref>PMID:2165278</ref> 
 
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{{ABSTRACT_PUBMED_17243678}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DPR OCA].  
[[2dpr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DPR OCA].  


==Reference==
==Reference==
The crystal structures of the calcium-bound con-G and con-T[K7gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif., Cnudde SE, Prorok M, Dai Q, Castellino FJ, Geiger JH, J Am Chem Soc. 2007 Feb 14;129(6):1586-93. Epub 2007 Jan 23. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17243678 17243678]
<ref group="xtra">PMID:017243678</ref><references group="xtra"/><references/>
[[Category: Castellino, F J.]]
[[Category: Castellino, F J.]]
[[Category: Cnudde, S E.]]
[[Category: Cnudde, S E.]]
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[[Category: Conantoxin]]
[[Category: Conantoxin]]
[[Category: Gla-containing]]
[[Category: Gla-containing]]
[[Category: Metal binding protein]]
[[Category: Nmdar antagonist]]
[[Category: Nmdar antagonist]]
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