4k6l: Difference between revisions
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{{STRUCTURE_4k6l| PDB=4k6l | SCENE= }} | {{STRUCTURE_4k6l| PDB=4k6l | SCENE= }} | ||
===Structure of Typhoid Toxin=== | ===Structure of Typhoid Toxin=== | ||
{{ABSTRACT_PUBMED_23842500}} | |||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4k6l]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi Salmonella enterica subsp. enterica serovar typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6L OCA]. | [[4k6l]] is a 7 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhi Salmonella enterica subsp. enterica serovar typhi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K6L OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023842500</ref><references group="xtra"/><references/> | |||
[[Category: Salmonella enterica subsp. enterica serovar typhi]] | [[Category: Salmonella enterica subsp. enterica serovar typhi]] | ||
[[Category: Galan,J.]] | [[Category: Galan,J.]] | ||
Revision as of 11:37, 24 July 2013
Structure of Typhoid Toxin
Template:ABSTRACT PUBMED 23842500
Function
[CDTB_SALTI] Produces a CDT (cytolethal distending toxin) activity, which causes DNA damage in intoxicated cells. This damage induces G2/M cell cycle arrest, chromatin fragmentation, cell distention and nucleus enlargement.
About this Structure
4k6l is a 7 chain structure with sequence from Salmonella enterica subsp. enterica serovar typhi. Full crystallographic information is available from OCA.
Reference
- Song J, Gao X, Galan JE. Structure and function of the Salmonella Typhi chimaeric A(2)B(5) typhoid toxin. Nature. 2013 Jul 18;499(7458):350-4. doi: 10.1038/nature12377. Epub 2013 Jul 10. PMID:23842500 doi:10.1038/nature12377
