4kpb: Difference between revisions
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{{STRUCTURE_4kpb| PDB=4kpb | SCENE= }} | |||
===Crystal structure of cytochrome P450 BM-3 R47E mutant=== | |||
{{ABSTRACT_PUBMED_23829560}} | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/CPXB_BACME CPXB_BACME]] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450. | |||
==About this Structure== | |||
[[4kpb]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_megaterium Bacillus megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPB OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023829560</ref><references group="xtra"/><references/> | |||
[[Category: Bacillus megaterium]] | |||
[[Category: Unspecific monooxygenase]] | |||
[[Category: Catalano, J.]] | |||
[[Category: McDermott, A E.]] | |||
[[Category: Sadre-Bazzaz, K.]] | |||
[[Category: Tong, L.]] | |||
[[Category: Heme-dependent stereospecific oxidation of substrate]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 12:58, 24 July 2013
Crystal structure of cytochrome P450 BM-3 R47E mutant
Template:ABSTRACT PUBMED 23829560
Function
[CPXB_BACME] Functions as a fatty acid monooxygenase. Catalyzes hydroxylation of medium and long-chain fatty acids at omega-1, omega-2 and omega-3 positions, with optimum chain lengths of 12-16 carbons (lauric, myristic, and palmitic acids). The reductase domain is required for electron transfer from NADP to cytochrome P450.
About this Structure
4kpb is a 2 chain structure with sequence from Bacillus megaterium. Full crystallographic information is available from OCA.
Reference
- Catalano J, Sadre-Bazzaz K, Amodeo GA, Tong L, McDermott AE. Structural Evidence: A Single Charged Residue Affects Substrate Binding in Cytochrome P450 BM-3. Biochemistry. 2013 Jul 6. PMID:23829560 doi:10.1021/bi4000645
