3wcy: Difference between revisions
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{{STRUCTURE_3wcy| PDB=3wcy | SCENE= }} | |||
===Murine Ifnar1 in complex with interferon-beta=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/INAR1_MOUSE INAR1_MOUSE]] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. [[http://www.uniprot.org/uniprot/IFNB_MOUSE IFNB_MOUSE]] Has antiviral, antibacterial and anticancer activities. | |||
==About this Structure== | |||
[[3wcy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WCY OCA]. | |||
[[Category: Mus musculus]] | |||
[[Category: Hertzog, P J.]] | |||
[[Category: Rossjohn, J.]] | |||
[[Category: Vivian, J P.]] | |||
[[Category: Weerd, N A.de.]] | |||
[[Category: Cytokine receptor]] | |||
[[Category: Cytokine receptor-cytokine complex]] | |||
[[Category: Fibronectin type iii]] | |||
[[Category: Helical cytokine]] | |||
[[Category: Interferon]] | |||
Revision as of 13:00, 24 July 2013
Murine Ifnar1 in complex with interferon-beta
Function
[INAR1_MOUSE] Associates with IFNAR2 to form the type I interferon receptor. Receptor for interferons alpha and beta. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. [IFNB_MOUSE] Has antiviral, antibacterial and anticancer activities.
About this Structure
3wcy is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
