Sandbox 126: Difference between revisions

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	== How does Ceftobiprole Work ==		== How does Ceftobiprole Work ==

	<scene name='37/372726/Ceftobiprole/2'>Ceftobiprole</scene> is able to inhibit PBP2a because additional chemical groups at <scene name='37/372726/Ceftobiprole/4'>the R2 position of the cephalosporin backbone</scene> are able to interact with additional amino acid residues in PBP2a; specifically Tyr446 and Met641. As a result of its tighter binding to PBP2a, ceftobiprole is able to more efficiently react with the serine active site residue and therefore inhibit the activity of PBP2a.		<scene name='37/372726/Ceftobiprole/2'>Ceftobiprole</scene> is able to inhibit PBP2a because additional chemical groups at <scene name='37/372726/Ceftobiprole/4'>the R2 position of the cephalosporin backbone</scene> are able to interact with additional amino acid residues in PBP2a; specifically <scene name='37/372726/Tyr446_residue/1'>Tyr446</scene> and Met641. As a result of its tighter binding to PBP2a, ceftobiprole is able to more efficiently react with the serine active site residue and therefore inhibit the activity of PBP2a.

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