2yjz: Difference between revisions
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{{STRUCTURE_2yjz| PDB=2yjz | SCENE= }} | {{STRUCTURE_2yjz| PDB=2yjz | SCENE= }} | ||
===Rat STEAP4 oxidoreductase domain complexed with NADP=== | ===Rat STEAP4 oxidoreductase domain complexed with NADP=== | ||
{{ABSTRACT_PUBMED_23733181}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/STEA4_RAT STEA4_RAT]] Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). | |||
==About this Structure== | ==About this Structure== | ||
[[2yjz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJZ OCA]. | [[2yjz]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YJZ OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023733181</ref><references group="xtra"/><references/> | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Fleming, M D.]] | [[Category: Fleming, M D.]] | ||
Revision as of 03:27, 1 August 2013
Rat STEAP4 oxidoreductase domain complexed with NADP
Template:ABSTRACT PUBMED 23733181
Function
[STEA4_RAT] Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Inhibits anchorage-independent cell proliferation. Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Play a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity).
About this Structure
2yjz is a 4 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Gauss GH, Kleven MD, Sendamarai AK, Fleming MD, Lawrence CM. The Crystal Structure of Six-transmembrane Epithelial Antigen of the Prostate 4 (Steap4), a Ferri/Cuprireductase, Suggests a Novel Interdomain Flavin-binding Site. J Biol Chem. 2013 Jul 12;288(28):20668-82. doi: 10.1074/jbc.M113.479154. Epub, 2013 Jun 3. PMID:23733181 doi:10.1074/jbc.M113.479154
