3vws: Difference between revisions
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{{STRUCTURE_3vws| PDB=3vws | SCENE= }} | {{STRUCTURE_3vws| PDB=3vws | SCENE= }} | ||
===Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107=== | ===Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107=== | ||
{{ABSTRACT_PUBMED_23408636}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/Q6DLV0_9FLAV Q6DLV0_9FLAV]] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774] | |||
==About this Structure== | ==About this Structure== | ||
[[3vws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VWS OCA]. | [[3vws]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Dengue_virus_3 Dengue virus 3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VWS OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023408636</ref><references group="xtra"/><references/> | |||
[[Category: Dengue virus 3]] | [[Category: Dengue virus 3]] | ||
[[Category: RNA-directed RNA polymerase]] | [[Category: RNA-directed RNA polymerase]] | ||
Revision as of 03:35, 1 August 2013
Dengue serotype 3 RNA-dependent RNA polymerase bound to NITD-107
Template:ABSTRACT PUBMED 23408636
Function
[Q6DLV0_9FLAV] Envelope protein E binding to host cell surface receptor is followed by virus internalization through clathrin-mediated endocytosis. Envelope protein E is subsequently involved in membrane fusion between virion and host late endosomes. Synthesized as a homodimer with prM which acts as a chaperone for envelope protein E. After cleavage of prM, envelope protein E dissociate from small envelope protein M and homodimerizes (By similarity).[SAAS:SAAS000336_004_099774]
About this Structure
3vws is a 1 chain structure with sequence from Dengue virus 3. Full crystallographic information is available from OCA.
Reference
- Noble CG, Lim SP, Chen YL, Liew CW, Yap L, Lescar J, Shi PY. Conformational flexibility of the dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor. J Virol. 2013 Feb 13. PMID:23408636 doi:10.1128/JVI.00045-13
