2j34: Difference between revisions
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==Overview== | ==Overview== | ||
Torsional scans of sulfonamide S-C bonds in small model systems of a | Torsional scans of sulfonamide S-C bonds in small model systems of a series of arylsulfonamide factor Xa inhibitors were performed in order to investigate if conformational effects can help to rationalise the observed SAR. Computational results were in good agreement with the experimental data indicating that the sulfonamide conformation plays an important role in determining the activity in this particular series of factor Xa inhibitors. | ||
==Disease== | ==Disease== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Chan, C.]] | [[Category: Chan, C.]] | ||
[[Category: Convery, M | [[Category: Convery, M A.]] | ||
[[Category: Senger, S.]] | [[Category: Senger, S.]] | ||
[[Category: Watson, N | [[Category: Watson, N S.]] | ||
[[Category: CA]] | [[Category: CA]] | ||
[[Category: GS6]] | [[Category: GS6]] | ||
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[[Category: zymogen]] | [[Category: zymogen]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 17:58:46 2008'' | ||
