4l5t: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4l5t|  PDB=4l5t  |  SCENE=  }}
===Crystal structure of the tetrameric p202 HIN2===
{{ABSTRACT_PUBMED_23850291}}


The entry 4l5t is ON HOLD
==Function==
[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> 


Authors: Yin, Q., Tian, Y., Wu, H.
==About this Structure==
[[4l5t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5T OCA].  


Description: Crystal structure of the tetrameric p202 HIN2
==Reference==
<ref group="xtra">PMID:023850291</ref><references group="xtra"/><references/>
[[Category: Mus musculus]]
[[Category: Tian, Y.]]
[[Category: Wu, H.]]
[[Category: Yin, Q.]]
[[Category: Dna binding protein]]
[[Category: Hin200]]
[[Category: Immune system]]
[[Category: Ob-fold]]
[[Category: Tetramerization]]