4l5t: Difference between revisions
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{{STRUCTURE_4l5t| PDB=4l5t | SCENE= }} | |||
===Crystal structure of the tetrameric p202 HIN2=== | |||
{{ABSTRACT_PUBMED_23850291}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/IFI2_MOUSE IFI2_MOUSE]] Inhibits the transcriptional activity of several transcription factors, including NF-kappa-B p50 and p65, FOS, JUN, E2F1, E2F4, MYOD1 and myogenin. Has anti-apoptotic effects due to inhibition of the transcriptional activity of p53. Binds dsDNA in the cytosol. Is involved in innate immune response and has anti-inflammatory activity. Inhibits caspase activation in response to cytosolic DNA and may inhibit the activation of the AIM2 inflammasome, probably via association with AIM2.<ref>PMID:16670293</ref> <ref>PMID:19131592</ref> | |||
==About this Structure== | |||
[[4l5t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L5T OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023850291</ref><references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | |||
[[Category: Tian, Y.]] | |||
[[Category: Wu, H.]] | |||
[[Category: Yin, Q.]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Hin200]] | |||
[[Category: Immune system]] | |||
[[Category: Ob-fold]] | |||
[[Category: Tetramerization]] | |||