4g8h: Difference between revisions
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{{STRUCTURE_4g8h| PDB=4g8h | SCENE= }} | {{STRUCTURE_4g8h| PDB=4g8h | SCENE= }} | ||
===Crystal structure of C-lobe of bovine lactoferrin complexed with licofelone at 1.88 A resolution=== | ===Crystal structure of C-lobe of bovine lactoferrin complexed with licofelone at 1.88 A resolution=== | ||
==Function== | |||
[[http://www.uniprot.org/uniprot/TRFL_BOVIN TRFL_BOVIN]] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactotransferrin has antimicrobial activity. The most effective inhibitory activity was seen against E.coli and P.aeruginosa.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> Lactoferricin B is an antimicrobial peptide. Inhibits the growth of Gram-negative and Gram-positive bacteria.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:8980754</ref> <ref>PMID:15222473</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4g8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8H OCA]. | [[4g8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G8H OCA]. | ||
==See Also== | |||
*[[Lactoferrin|Lactoferrin]] | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Bos taurus]] | [[Category: Bos taurus]] | ||
[[Category: Gautam, L.]] | [[Category: Gautam, L.]] | ||
