4de5: Difference between revisions
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{{STRUCTURE_4de5| PDB=4de5 | SCENE= }} | {{STRUCTURE_4de5| PDB=4de5 | SCENE= }} | ||
===Pantothenate synthetase in complex with fragment 6=== | ===Pantothenate synthetase in complex with fragment 6=== | ||
{{ABSTRACT_PUBMED_23872845}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PANC_MYCTU PANC_MYCTU]] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.<ref>PMID:11669627</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4de5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DE5 OCA]. | [[4de5]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DE5 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023872845</ref><references group="xtra"/><references/> | |||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
[[Category: Pantoate--beta-alanine ligase]] | [[Category: Pantoate--beta-alanine ligase]] | ||
Revision as of 19:22, 7 August 2013
Pantothenate synthetase in complex with fragment 6
Template:ABSTRACT PUBMED 23872845
Function
[PANC_MYCTU] Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.[1]
About this Structure
4de5 is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Silvestre HL, Blundell TL, Abell C, Ciulli A. Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery. Proc Natl Acad Sci U S A. 2013 Jul 19. PMID:23872845 doi:10.1073/pnas.1304045110
