4l6s: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===PARP complexed with benzo[1,4]oxazin-3-one inhibitor===

~~The entry 4l6s~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>

~~Authors~~: ~~Dougan, D~~.R.~~, Mol C~~.D.~~, Lawson J~~.D.

==About this Structure==

[[4l6s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6S OCA].

~~Description~~: ~~PARP complexed with benzo~~[1,4]~~oxazin~~-3-~~one~~ inhibitor.

==Reference==

[[Category: Homo sapiens]]

[[Category: C D., Mol.]]

[[Category: Dougan, D R.]]

[[Category: J D., Lawson.]]

[[Category: Dna repair enzyme]]

[[Category: Dna single-strand break repair sensitize tumor]]

[[Category: Drd]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4l6s|  PDB=4l6s  |  SCENE=  }}
+===PARP complexed with benzo[1,4]oxazin-3-one inhibitor===
+{{ABSTRACT_PUBMED_23850199}}
-The entry 4l6s is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref>
-Authors: Dougan, D.R., Mol C.D., Lawson J.D.
+==About this Structure==
+[[4l6s]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6S OCA].
-Description: PARP complexed with benzo[1,4]oxazin-3-one inhibitor.
+==Reference==
+<ref group="xtra">PMID:023850199</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: C D., Mol.]]
+[[Category: Dougan, D R.]]
+[[Category: J D., Lawson.]]
+[[Category: Dna repair enzyme]]
+[[Category: Dna single-strand break repair sensitize tumor]]
+[[Category: Drd]]
+[[Category: Transferase-transferase inhibitor complex]]