4bul: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases===

~~The entry 4bul is ON HOLD until sometime~~ in the ~~future~~

==Function==

[[http://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).

~~Authors~~: Miles, T.J., Hennessy, A.J., Bax, B., Brooks, G., Brown, B.S., Brown, P., Cailleau, N., Chen, D., Dabbs, S., Davies, D.T., Esken, J.M., Giordano, I., Hoover, J.L., Huang, J., Jones, G.E., Sukmar, S.K.K., Spitzfaden, C., Markwell, R.E., Minthorn, E.A., Rittenhouse, S., Gwynn, M.N.~~, Pearson, N~~.D.

==About this Structure==

[[4bul]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUL OCA].

~~Description~~: ~~Novel hydroxyl tricyclics (e~~.g. ~~GSK966587) as potent inhibitors of bacterial type IIA topoisomerases~~

==Reference==

[[Category: Bax, B.]]

[[Category: Brooks, G.]]

[[Category: Brown, B S.]]

[[Category: Brown, P.]]

[[Category: Cailleau, N.]]

[[Category: Chen, D.]]

[[Category: Dabbs, S.]]

[[Category: Davies, D T.]]

[[Category: Esken, J M.]]

[[Category: Giordano, I.]]

[[Category: Gwynn, M N.]]

[[Category: Hennessy, A J.]]

[[Category: Hoover, J L.]]

[[Category: Huang, J.]]

[[Category: Jones, G E.]]

[[Category: Markwell, R E.]]

[[Category: Miles, T J.]]

[[Category: Minthorn, E A.]]

[[Category: Pearson, N D.]]

[[Category: Rittenhouse, S.]]

[[Category: Spitzfaden, C.]]

[[Category: Sukmar, S K.K.]]

[[Category: Isomerase]]

[[Category: Nbti]]

[[Category: Type iia topoisomerase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bul|  PDB=4bul  |  SCENE=  }}
+===Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases===
+{{ABSTRACT_PUBMED_20686482}}
-The entry 4bul is ON HOLD  until sometime in the future
+==Function==
+[[http://www.uniprot.org/uniprot/GYRB_STAAN GYRB_STAAN]] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity).
-Authors: Miles, T.J., Hennessy, A.J., Bax, B., Brooks, G., Brown, B.S., Brown, P., Cailleau, N., Chen, D., Dabbs, S., Davies, D.T., Esken, J.M., Giordano, I., Hoover, J.L., Huang, J., Jones, G.E., Sukmar, S.K.K., Spitzfaden, C., Markwell, R.E., Minthorn, E.A., Rittenhouse, S., Gwynn, M.N., Pearson, N.D.
+==About this Structure==
+[[4bul]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUL OCA].
-Description: Novel hydroxyl tricyclics (e.g. GSK966587) as potent inhibitors of bacterial type IIA topoisomerases
+==Reference==
+<ref group="xtra">PMID:020686482</ref><references group="xtra"/><references/>
+[[Category: Bax, B.]]
+[[Category: Brooks, G.]]
+[[Category: Brown, B S.]]
+[[Category: Brown, P.]]
+[[Category: Cailleau, N.]]
+[[Category: Chen, D.]]
+[[Category: Dabbs, S.]]
+[[Category: Davies, D T.]]
+[[Category: Esken, J M.]]
+[[Category: Giordano, I.]]
+[[Category: Gwynn, M N.]]
+[[Category: Hennessy, A J.]]
+[[Category: Hoover, J L.]]
+[[Category: Huang, J.]]
+[[Category: Jones, G E.]]
+[[Category: Markwell, R E.]]
+[[Category: Miles, T J.]]
+[[Category: Minthorn, E A.]]
+[[Category: Pearson, N D.]]
+[[Category: Rittenhouse, S.]]
+[[Category: Spitzfaden, C.]]
+[[Category: Sukmar, S K.K.]]
+[[Category: Isomerase]]
+[[Category: Nbti]]
+[[Category: Type iia topoisomerase]]