4kyk: Difference between revisions
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{{STRUCTURE_4kyk| PDB=4kyk | SCENE= }} | |||
===Crystal structure of mouse glyoxalase I complexed with indomethacin=== | |||
{{ABSTRACT_PUBMED_23857942}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/LGUL_MOUSE LGUL_MOUSE]] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity). | |||
==About this Structure== | |||
[[4kyk]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KYK OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023857942</ref><references group="xtra"/><references/> | |||
[[Category: Lactoylglutathione lyase]] | |||
[[Category: Mus musculus]] | |||
[[Category: Chen, S.]] | |||
[[Category: Chen, Y.]] | |||
[[Category: Yuan, M.]] | |||
[[Category: Zhai, J.]] | |||
[[Category: Zhang, H.]] | |||
[[Category: Zhang, L.]] | |||
[[Category: Zhao, Y.]] | |||
[[Category: Lactoylglutachione lyase]] | |||
[[Category: Lyase-lyase inhibitor complex]] | |||
Revision as of 20:56, 7 August 2013
Crystal structure of mouse glyoxalase I complexed with indomethacin
Template:ABSTRACT PUBMED 23857942
Function
[LGUL_MOUSE] Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B (By similarity).
About this Structure
4kyk is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Zhai J, Zhang H, Zhang L, Zhao Y, Chen S, Chen Y, Peng X, Li Q, Yuan M, Hu X. Zopolrestat as a Human Glyoxalase I Inhibitor and Its Structural Basis. ChemMedChem. 2013 Jul 15. doi: 10.1002/cmdc.201300243. PMID:23857942 doi:10.1002/cmdc.201300243
