4g3p: Difference between revisions
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{{STRUCTURE_4g3p| PDB=4g3p | SCENE= }} | |||
===Crystal structure of GlmU from Mycobacterium tuberculosis Snapshot 3=== | |||
The | ==Function== | ||
[[http://www.uniprot.org/uniprot/GLMU_MYCTU GLMU_MYCTU]] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.<ref>PMID:19237750</ref> <ref>PMID:19121323</ref> | |||
==About this Structure== | |||
[[4g3p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G3P OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Mycobacterium tuberculosis]] | |||
[[Category: Jagtap, P A.]] | |||
[[Category: Prakash, B.]] | |||
[[Category: Verma, S K.]] | |||
[[Category: Acetyltransferase]] | |||
[[Category: Bifunctional]] | |||
[[Category: Cell shape]] | |||
[[Category: Cell wall biogenesis/degradation]] | |||
[[Category: Left-handed-beta-helix]] | |||
[[Category: Metal-binding]] | |||
[[Category: Multifunctional enzyme]] | |||
[[Category: Nucleotidyltransferase]] | |||
[[Category: Peptidoglycan synthesis]] | |||
[[Category: Pyrophosphorylase]] | |||
[[Category: Rossmann-like fold]] | |||
[[Category: Transferase]] | |||
Revision as of 21:01, 7 August 2013
Crystal structure of GlmU from Mycobacterium tuberculosis Snapshot 3
Function
[GLMU_MYCTU] Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.[1] [2]
About this Structure
4g3p is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- ↑ Zhang Z, Bulloch EM, Bunker RD, Baker EN, Squire CJ. Structure and function of GlmU from Mycobacterium tuberculosis. Acta Crystallogr D Biol Crystallogr. 2009 Mar;65(Pt 3):275-83. Epub 2009, Feb 20. PMID:19237750 doi:10.1107/S0907444909001036
- ↑ Parikh A, Verma SK, Khan S, Prakash B, Nandicoori VK. PknB-mediated phosphorylation of a novel substrate, N-acetylglucosamine-1-phosphate uridyltransferase, modulates its acetyltransferase activity. J Mol Biol. 2009 Feb 20;386(2):451-64. Epub 2008 Dec 24. PMID:19121323 doi:10.1016/j.jmb.2008.12.031
