4kud: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4kud|  PDB=4kud  |  SCENE=  }}
===Crystal structure of N-terminal acetylated Sir3 BAH domain D205N mutant in complex with yeast nucleosome core particle===


The entry 4kud is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/SIR3_YEAST SIR3_YEAST]] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form. [[http://www.uniprot.org/uniprot/H2B1_YEAST H2B1_YEAST]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11973294</ref> <ref>PMID:12152067</ref> <ref>PMID:14752010</ref> <ref>PMID:15280549</ref> <ref>PMID:15652479</ref> <ref>PMID:15970663</ref> <ref>PMID:15632126</ref> <ref>PMID:15632065</ref> <ref>PMID:16598039</ref>  [[http://www.uniprot.org/uniprot/H2A2_YEAST H2A2_YEAST]] Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.<ref>PMID:11140636</ref> <ref>PMID:15458641</ref> <ref>PMID:15610741</ref> <ref>PMID:16299494</ref>  


Authors: Yang, D., Fang, Q., Wang, M., Ren, R., Wang, H., He, M., Sun, Y., Yang, N., Xu, R.M.
==About this Structure==
[[4kud]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KUD OCA].  


Description: Crystal structure of N-terminal acetylated Sir3 BAH domain D205N mutant in complex with yeast nucleosome core particle
==Reference==
<references group="xtra"/><references/>
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Fang, Q.]]
[[Category: He, M.]]
[[Category: Ren, R.]]
[[Category: Sun, Y.]]
[[Category: Wang, H.]]
[[Category: Wang, M.]]
[[Category: Xu, R M.]]
[[Category: Yang, D.]]
[[Category: Yang, N.]]
[[Category: Bah domain]]
[[Category: Nucleosome]]
[[Category: Nucleus]]
[[Category: Proteprotein-dna complex]]
[[Category: Silencing]]
[[Category: Structural protein-transcription-dna complex]]
Retrieved from "https://proteopedia.org/4kud"