4lrg: Difference between revisions
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{{STRUCTURE_4lrg| PDB=4lrg | SCENE= }} | |||
===Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide=== | |||
==Disease== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
==About this Structure== | |||
[[4lrg]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LRG OCA]. | |||
==Reference== | |||
<references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Albrecht, B.]] | |||
[[Category: Audia, J.]] | |||
[[Category: Bellon, S.]] | |||
[[Category: Bergeron, L.]] | |||
[[Category: Birudukota, S.]] | |||
[[Category: Bryant, B.]] | |||
[[Category: Cote, A.]] | |||
[[Category: Gehling, V.]] | |||
[[Category: Harmange, J C.]] | |||
[[Category: Hewitt, M.]] | |||
[[Category: Jayaram, H.]] | |||
[[Category: Joshi, S.]] | |||
[[Category: Leblanc, Y.]] | |||
[[Category: Mertz, J.]] | |||
[[Category: Nandana, B S.]] | |||
[[Category: Nasveschuk, C.]] | |||
[[Category: Pardo, E.]] | |||
[[Category: Poy, F.]] | |||
[[Category: Sandy, P.]] | |||
[[Category: Sankaranarayanan, R.]] | |||
[[Category: Sims, R.]] | |||
[[Category: Taylor, A.]] | |||
[[Category: Vaswani, R.]] | |||
[[Category: Yellapuntala, S.]] | |||
[[Category: Bet inhibitor]] | |||
[[Category: Brd4 first bromodomain]] | |||
[[Category: Transcription regulator-inhibitor complex]] | |||
Revision as of 21:20, 7 August 2013
Structure of BRD4 bromodomain 1 with a dimethyl thiophene isoxazole azepine carboxamide
Disease
[BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2]
Function
[BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity).
About this Structure
4lrg is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- ↑ French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA. BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003 Jan 15;63(2):304-7. PMID:12543779
- ↑ French CA, Miyoshi I, Aster JC, Kubonishi I, Kroll TG, Dal Cin P, Vargas SO, Perez-Atayde AR, Fletcher JA. BRD4 bromodomain gene rearrangement in aggressive carcinoma with translocation t(15;19). Am J Pathol. 2001 Dec;159(6):1987-92. PMID:11733348 doi:10.1016/S0002-9440(10)63049-0
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Homo sapiens
- Albrecht, B.
- Audia, J.
- Bellon, S.
- Bergeron, L.
- Birudukota, S.
- Bryant, B.
- Cote, A.
- Gehling, V.
- Harmange, J C.
- Hewitt, M.
- Jayaram, H.
- Joshi, S.
- Leblanc, Y.
- Mertz, J.
- Nandana, B S.
- Nasveschuk, C.
- Pardo, E.
- Poy, F.
- Sandy, P.
- Sankaranarayanan, R.
- Sims, R.
- Taylor, A.
- Vaswani, R.
- Yellapuntala, S.
- Bet inhibitor
- Brd4 first bromodomain
- Transcription regulator-inhibitor complex
