3voq: Difference between revisions

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~~[[Image:3voq.jpg|left|200px]]~~

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===Crystal structure of the pleckstrin homology domain of human Sin1, a TORC2 subunit===

==Function==

[[http://www.uniprot.org/uniprot/SIN1_HUMAN SIN1_HUMAN]] Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription.<ref>PMID:15988011</ref> <ref>PMID:16962653</ref> <ref>PMID:17054722</ref> <ref>PMID:17043309</ref> <ref>PMID:17303383</ref>

==About this Structure==

[[3voq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VOQ OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Matsuura, Y.]]

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-[[Image:3voq.jpg|left|200px]]
-<!--
-The line below this paragraph, containing "STRUCTURE_3voq", creates the "Structure Box" on the page.
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-or leave the SCENE parameter empty for the default display.
--->
 {{STRUCTURE_3voq|  PDB=3voq  |  SCENE=  }}
 ===Crystal structure of the pleckstrin homology domain of human Sin1, a TORC2 subunit===
+{{ABSTRACT_PUBMED_22505404}}
+==Function==
+[[http://www.uniprot.org/uniprot/SIN1_HUMAN SIN1_HUMAN]] Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription.<ref>PMID:15988011</ref> <ref>PMID:16962653</ref> <ref>PMID:17054722</ref> <ref>PMID:17043309</ref> <ref>PMID:17303383</ref>
 ==About this Structure==
 [[3voq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VOQ OCA].
+==Reference==
+<ref group="xtra">PMID:022505404</ref><references group="xtra"/><references/>
 [[Category: Homo sapiens]]
 [[Category: Matsuura, Y.]]