3vxv: Difference between revisions
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{{STRUCTURE_3vxv| PDB=3vxv | SCENE= }} | {{STRUCTURE_3vxv| PDB=3vxv | SCENE= }} | ||
===Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence=== | ===Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence=== | ||
{{ABSTRACT_PUBMED_23316048}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/MBD4_MOUSE MBD4_MOUSE]] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein. | |||
==About this Structure== | ==About this Structure== | ||
[[3vxv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXV OCA]. | [[3vxv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VXV OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023316048</ref><references group="xtra"/><references/> | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Arita, K.]] | [[Category: Arita, K.]] | ||
Revision as of 06:32, 14 August 2013
Crystal structure of methyl CpG Binding Domain of MBD4 in complex with the 5mCG/TG sequence
Template:ABSTRACT PUBMED 23316048
Function
[MBD4_MOUSE] Mismatch-specific DNA N-glycosylase involved in DNA repair. Has thymine glycosylase activity and is specific for G:T mismatches within methylated and unmethylated CpG sites. Can also remove uracil or 5-fluorouracil in G:U mismatches. Has no lyase activity. Was first identified as methyl-CpG-binding protein.
About this Structure
3vxv is a 3 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
- Otani J, Arita K, Kato T, Kinoshita M, Kimura H, Suetake I, Tajima S, Ariyoshi M, Shirakawa M. Structural basis of the versatile DNA recognition ability of the methyl-CpG binding domain of methyl-CpG binding domain protein 4. J Biol Chem. 2013 Mar 1;288(9):6351-62. doi: 10.1074/jbc.M112.431098. Epub 2013, Jan 10. PMID:23316048 doi:10.1074/jbc.M112.431098
