3vw7: Difference between revisions
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{{STRUCTURE_3vw7| PDB=3vw7 | SCENE= }} | {{STRUCTURE_3vw7| PDB=3vw7 | SCENE= }} | ||
===Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom=== | ===Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom=== | ||
{{ABSTRACT_PUBMED_23222541}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PAR1_HUMAN PAR1_HUMAN]] High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.<ref>PMID:10079109</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[3vw7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VW7 OCA]. | [[3vw7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3VW7 OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023222541</ref><references group="xtra"/><references/> | |||
[[Category: Lysozyme]] | [[Category: Lysozyme]] | ||
[[Category: Arlow, D H.]] | [[Category: Arlow, D H.]] | ||
Revision as of 06:35, 14 August 2013
Crystal structure of human protease-activated receptor 1 (PAR1) bound with antagonist vorapaxar at 2.2 angstrom
Template:ABSTRACT PUBMED 23222541
Function
[PAR1_HUMAN] High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.[1]
About this Structure
3vw7 is a 1 chain structure. Full crystallographic information is available from OCA.
Reference
- Zhang C, Srinivasan Y, Arlow DH, Fung JJ, Palmer D, Zheng Y, Green HF, Pandey A, Dror RO, Shaw DE, Weis WI, Coughlin SR, Kobilka BK. High-resolution crystal structure of human protease-activated receptor 1. Nature. 2012 Dec 20;492(7429):387-92. doi: 10.1038/nature11701. Epub 2012 Dec 9. PMID:23222541 doi:10.1038/nature11701
- ↑ Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103(6):879-87. PMID:10079109 doi:10.1172/JCI6042
Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Lysozyme
- Arlow, D H.
- Coughlin, S R.
- Dror, R O.
- Fung, J J.
- Green, H F.
- Kobilka, B K.
- Palmer, D.
- Pandey, A.
- Shaw, D E.
- Srinivasan, Y.
- Weis, W I.
- Zhang, C.
- Zheng, Y.
- Antagonist vorapaxar
- G protein-coupled receptor
- High resolution structure
- Inactive conformation
- Membrane protein
- Protease-activated receptor 1
- Signaling protein
- Signaling protein-antagonist complex
- Thrombin receptor-antagonist complex
