2jiw: Difference between revisions
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==Overview== | ==Overview== | ||
The synthesis of an analogue of 6-epi-valienamine bearing an acetamido | The synthesis of an analogue of 6-epi-valienamine bearing an acetamido group and its characterisation as an inhibitor of beta-N-acetylglucosaminidases are described. The compound is a good inhibitor of both human O-GlcNAcase and human beta-hexosaminidase, as well as two bacterial beta-N-acetylglucosaminidases. A 3-D structure of the complex of Bacteroides thetaiotaomicron BtGH84 with the inhibitor shows the unsaturated ring is surprisingly distorted away from its favoured solution phase conformation and reveals potential for improved inhibitor potency. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Beta-N-acetylhexosaminidase]] | [[Category: Beta-N-acetylhexosaminidase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Davies, G | [[Category: Davies, G J.]] | ||
[[Category: Dennis, R | [[Category: Dennis, R J.]] | ||
[[Category: BEU]] | [[Category: BEU]] | ||
[[Category: enzyme]] | [[Category: enzyme]] | ||
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[[Category: o-glcnacase]] | [[Category: o-glcnacase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:03:48 2008'' | ||
