4lxe: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Bcl_2-Navitoclax Analog (with Indole) Complex===

~~The entry 4lxe is ON HOLD~~

==Disease==

[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.

~~Authors~~: ~~Park, C~~.H.

==Function==

[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>

~~Description~~: ~~Bcl_2~~-~~Navitoclax Analog (with Indole) Complex~~

==About this Structure==

[[4lxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXE OCA].

==Reference==

[[Category: Ochroconis lascauxensis]]

[[Category: Park, C H.]]

[[Category: 8 helice]]

[[Category: Apoptosis regulator-inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4lxe|  PDB=4lxe  |  SCENE=  }}
+===Bcl_2-Navitoclax Analog (with Indole) Complex===
+{{ABSTRACT_PUBMED_23291630}}
-The entry 4lxe is ON HOLD
+==Disease==
+[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Note=A chromosomal aberration involving BCL2 has been found in chronic lymphatic leukemia. Translocation t(14;18)(q32;q21) with immunoglobulin gene regions. BCL2 mutations found in non-Hodgkin lymphomas carrying the chromosomal translocation could be attributed to the Ig somatic hypermutation mechanism resulting in nucleotide transitions.
-Authors: Park, C.H.
+==Function==
+[[http://www.uniprot.org/uniprot/BCL2_HUMAN BCL2_HUMAN]] Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).<ref>PMID:18570871</ref>
-Description: Bcl_2-Navitoclax Analog (with Indole) Complex
+==About this Structure==
+[[4lxe]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXE OCA].
+==Reference==
+<ref group="xtra">PMID:023291630</ref><references group="xtra"/><references/>
+[[Category: Ochroconis lascauxensis]]
+[[Category: Park, C H.]]
+[[Category: 8 helice]]
+[[Category: Apoptosis regulator-inhibitor complex]]