4ijh: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A===

~~The entry 4ijh is ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref> Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>

~~Authors~~: ~~Feldkamp, M~~.D.~~, Patrone, J~~.~~D., Kennedy, J.P., Frank, A.O., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Fesik, S~~.W.~~, Chazin, W~~.J.

==About this Structure==

[[4ijh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA].

~~Description~~:

==Reference==

[[Category: Homo sapiens]]

[[Category: Chazin, W J.]]

[[Category: Feldkamp, M D.]]

[[Category: Fesik, S W.]]

[[Category: Frank, A O.]]

[[Category: Kennedy, J P.]]

[[Category: Patrone, J D.]]

[[Category: Pelz, N F.]]

[[Category: Rossanese, O W.]]

[[Category: Vangamudi, B.]]

[[Category: Waterson, A G.]]

[[Category: Dna binding protein-inhibitor complex]]

[[Category: Ob-fold]]

[[Category: Protein-protein interaction]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4ijh|  PDB=4ijh  |  SCENE=  }}
+===Fragment-based Discovery of Protein-Protein Interaction Inhibitors of Replication Protein A===
+{{ABSTRACT_PUBMED_23914285}}
-The entry 4ijh is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/RFA1_HUMAN RFA1_HUMAN]] Plays an essential role in several cellular processes in DNA metabolism including replication, recombination and DNA repair. Binds and subsequently stabilizes single-stranded DNA intermediates and thus prevents complementary DNA from reannealing.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>   Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S-phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange.<ref>PMID:19116208</ref> <ref>PMID:19996105</ref>
-Authors: Feldkamp, M.D., Patrone, J.D., Kennedy, J.P., Frank, A.O., Vangamudi, B., Pelz, N.F., Rossanese, O.W., Waterson, A.G., Fesik, S.W., Chazin, W.J.
+==About this Structure==
+[[4ijh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IJH OCA].
-Description:
+==Reference==
+<ref group="xtra">PMID:023914285</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Chazin, W J.]]
+[[Category: Feldkamp, M D.]]
+[[Category: Fesik, S W.]]
+[[Category: Frank, A O.]]
+[[Category: Kennedy, J P.]]
+[[Category: Patrone, J D.]]
+[[Category: Pelz, N F.]]
+[[Category: Rossanese, O W.]]
+[[Category: Vangamudi, B.]]
+[[Category: Waterson, A G.]]
+[[Category: Dna binding protein-inhibitor complex]]
+[[Category: Ob-fold]]
+[[Category: Protein-protein interaction]]