2m85: Difference between revisions
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{{STRUCTURE_2m85| PDB=2m85 | SCENE= }} | |||
===PHD Domain from Human SHPRH=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/SHPRH_HUMAN SHPRH_HUMAN]] E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'.<ref>PMID:17130289</ref> <ref>PMID:17108083</ref> <ref>PMID:18719106</ref> | |||
==About this Structure== | |||
[[2m85]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M85 OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023907177</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Almeida, F C.L.]] | |||
[[Category: Bezsonova, I.]] | |||
[[Category: Korzhnev, D M.]] | |||
[[Category: Machado, L E.S F.]] | |||
[[Category: Pozhidaeva, A.]] | |||
[[Category: Pustovalova, Y.]] | |||
[[Category: Helicase]] | |||
[[Category: Histone linker]] | |||
[[Category: Hydrolase]] | |||
[[Category: Ligase]] | |||
[[Category: Phd finger]] | |||
[[Category: Ring finger]] | |||
[[Category: Shprh]] | |||
[[Category: Snf2]] | |||