Sandbox 124: Difference between revisions

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residues in PBP2a; specifically  
residues in PBP2a; specifically  
<scene name='37/372724/Tyr446_and_met641_label/2'>Tyr446 and Met641</scene>.
<scene name='37/372724/Tyr446_and_met641_label/2'>Tyr446 and Met641</scene>.
As a result of its <scene name='37/372724/R2_interaction/4'>tighter binding</scene> to PBP2a, <scene name='37/372724/Tyr446_and_met641_label/3'>ceftobiprole </scene>, shown as colors of the atom types ([[CPK]]), is able to more efficiently react with the serine active site residue and therefore inhibit the activity of PBP2a.
As a result of ceftobiprole <scene name='37/372724/R2_interaction/4'>tighter binding</scene> to PBP2a as highlighted in green , <scene name='37/372724/Tyr446_and_met641_label/3'>the medicine </scene>, shown as colors of the atom types ([[CPK]]), is able to more efficiently react with the serine active site residue and therefore inhibit the activity of PBP2a.
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