Avidin: Difference between revisions
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{{Clear}} | {{Clear}} | ||
<applet load='2avi' size='300' frame='true' align='right' caption='Two monomers of the tetramer Avidin' /> | <applet load='2avi' size='300' frame='true' align='right' caption='Two monomers of the tetramer Avidin complex with biotin (PDB code [[2avi]])' /> | ||
The binding affinity of biotin for the avidin <scene name='Sandbox-test/Biotin_binding_avidin/1'>receptors</scene> is very hight or in other words, the strength of the interations between the biotin and the avidin receptors is so strong that washing the biotin-avidin complex is not enough to remove the ligand from its pocket. This is not even possible by adding more biotin molecules to the system avidin-biotin. Once a biotin has bound a pocket in the avidin, it is almost imposible to remove it in a biologica system! | The binding affinity of biotin for the avidin <scene name='Sandbox-test/Biotin_binding_avidin/1'>receptors</scene> is very hight or in other words, the strength of the interations between the biotin and the avidin receptors is so strong that washing the biotin-avidin complex is not enough to remove the ligand from its pocket. This is not even possible by adding more biotin molecules to the system avidin-biotin. Once a biotin has bound a pocket in the avidin, it is almost imposible to remove it in a biologica system! | ||
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== Streptavidin == | == Streptavidin == | ||
[[2bc3]], [[2iza]], [[2izb]], [[2izc]], [[2izd]], [[2ize]], [[2rta]], [[2rtb]], [[2rtc]], [[3ry1]] - StrAv - ''Streptomyces avidinii''<br /> | [[2bc3]], [[2iza]], [[2izb]], [[2izc]], [[2izd]], [[2ize]], [[2rta]], [[2rtb]], [[2rtc]], [[3ry1]], [[4gd9]]. [[4gda]], [[4gjs]] - StrAv - ''Streptomyces avidinii''<br /> | ||
[[3mm0]], [[3pk2]], [[3rds]], [[3rdx]], [[3re5]], [[3re6]] - StrAv (mutant) <br /> | [[3mm0]], [[3pk2]], [[3rds]], [[3rdx]], [[3re5]], [[3re6]], [[4gjv]] - StrAv (mutant) <br /> | ||
[[1swa]], [[1swb]], [[1swc]], [[1ry1]] - StrAv core<br /> | [[1swa]], [[1swb]], [[1swc]], [[1ry1]] - StrAv core<br /> | ||
[[1swh]], [[1swj]], [[1swl]], [[1swo]], [[1swq]], [[1sws]], [[2y3e]], [[3t6l]] - StrAv core (mutant)<br /> | [[1swh]], [[1swj]], [[1swl]], [[1swo]], [[1swq]], [[1sws]], [[2y3e]], [[3t6l]] - StrAv core (mutant)<br /> | ||
[[4jnj]] – StrAv/rhizavidin<br /> | |||
[[4jo6]] – StrAv + SBP-TAG<br /> | |||
== Streptavidin binary complexes== | == Streptavidin binary complexes== | ||
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[[2izk]], [[2rth]], [[2rti]], [[2rtj]], [[2rtk]] – StrAV+glycouril<br /> | [[2izk]], [[2rth]], [[2rti]], [[2rtj]], [[2rtk]] – StrAV+glycouril<br /> | ||
[[2qcb]], [[2wpu]] – StrAv+Ru ligand | [[2qcb]], [[2wpu]] – StrAv+Ru ligand | ||
== Rhizavidin == | == Rhizavidin == | ||
[[3ew1]] – RhiAv – ''Rhizobium etli''<br /> | [[3ew1]] – RhiAv – ''Rhizobium etli''<br /> | ||
[[3ew2]] – RhiAV+biotin<br /> | [[3ew2]] – RhiAV+biotin<br /> | ||
== Xenavidin == | == Xenavidin == | ||
[[2uz2]], [[2uyw]] – XenAv – frog<br /> | [[2uz2]], [[2uyw]] – XenAv – frog<br /> | ||
== Tamavidin == | == Tamavidin == | ||
[[2zsc]] – TanAv – Tamogitake mushroom | [[2zsc]] – TanAv – Tamogitake mushroom | ||
'''Bradavidin''' | |||
[[4ggr]], [[4ggt]] – Av – ''Bradyrhizobium japonicum''<br /> | |||
== AVR2 == | == AVR2 == | ||
