4bwx: Difference between revisions
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{{STRUCTURE_4bwx| PDB=4bwx | SCENE= }} | |||
===Structure of Neurospora crassa PAN3 pseudokinase mutant=== | |||
{{ABSTRACT_PUBMED_23932717}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/PAN3_NEUCR PAN3_NEUCR]] Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex involved in cytoplasmic mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein pab-1. Deadenylation of the 3'-tail to a length that is too short to bind pab-1 induces mRNA decay. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. pan-3 acts as a positive regulator for PAN activity, recruiting pan-2 to mRNA via its interaction with pab-1 (By similarity). | |||
==About this Structure== | |||
[[4bwx]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Neurospora_crassa Neurospora crassa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BWX OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023932717</ref><references group="xtra"/><references/> | |||
[[Category: Neurospora crassa]] | |||
[[Category: Boland, A.]] | |||
[[Category: Christie, M.]] | |||
[[Category: Huntzinger, E.]] | |||
[[Category: Izaurralde, E.]] | |||
[[Category: Weichenrieder, O.]] | |||
[[Category: Deadenylase]] | |||
[[Category: Gene regulation]] | |||
[[Category: Mirna]] | |||
[[Category: Mrna decay]] | |||
[[Category: Pan2]] | |||