4l9u: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Structure of C-terminal coiled coil of RasGRP1===

~~The~~ entry ~~4l9u is ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.

~~Authors~~: ~~Iwig, J~~.S.~~, Vercoulen, Y~~.~~, Das, R~~.~~, Barros,~~ T., ~~Limnander~~, A., ~~Che, Y~~.~~, Pelton, J.G., Wemmer, D.E., Roose, J.P., Kuriyan, J~~.

==Function==

[[http://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN]] Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation.<ref>PMID:10807788</ref> <ref>PMID:12839994</ref> <ref>PMID:12782630</ref> <ref>PMID:12845332</ref> <ref>PMID:15060167</ref> <ref>PMID:15184873</ref> <ref>PMID:15899849</ref>

~~Description~~: ~~Structure of C~~-~~terminal coiled coil of RasGRP1~~

==About this Structure==

[[4l9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9U OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: Barros, T.]]

[[Category: Che, Y.]]

[[Category: Das, R.]]

[[Category: Iwig, J S.]]

[[Category: Kuriyan, J.]]

[[Category: Limnander, A.]]

[[Category: Pelton, J G.]]

[[Category: Roose, J P.]]

[[Category: Vercoulen, Y.]]

[[Category: Wemmer, D E.]]

[[Category: Signaling protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4l9u|  PDB=4l9u  |  SCENE=  }}
+===Structure of C-terminal coiled coil of RasGRP1===
+{{ABSTRACT_PUBMED_23908768}}
-The entry 4l9u is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN]] Disease susceptibility is associated with variations affecting the gene represented in this entry. Aberrantly spliced isoforms and/or diminished levels of RASGRP1 are found in a cohort of SLE patients raising the possibility that dysregulation of this signaling protein contributes to the development of autoimmunity in a subset of SLE patients.
-Authors: Iwig, J.S., Vercoulen, Y., Das, R., Barros, T., Limnander, A., Che, Y., Pelton, J.G., Wemmer, D.E., Roose, J.P., Kuriyan, J.
+==Function==
+[[http://www.uniprot.org/uniprot/GRP1_HUMAN GRP1_HUMAN]] Functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. Activates the Erk/MAP kinase cascade. Couples T-lymphocytes and B-lymphocytes antigen receptors to the activation of Ras. Hence, regulates T-cells and B-cells development, homeostasis and differentiation. Functions also in FcERI-evoked degranulation and cytokine secretion by mast cells, regulating allergic responses. May also function in other cell types differentiation.<ref>PMID:10807788</ref> <ref>PMID:12839994</ref> <ref>PMID:12782630</ref> <ref>PMID:12845332</ref> <ref>PMID:15060167</ref> <ref>PMID:15184873</ref> <ref>PMID:15899849</ref>
-Description: Structure of C-terminal coiled coil of RasGRP1
+==About this Structure==
+[[4l9u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L9U OCA].
+==Reference==
+<ref group="xtra">PMID:023908768</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Barros, T.]]
+[[Category: Che, Y.]]
+[[Category: Das, R.]]
+[[Category: Iwig, J S.]]
+[[Category: Kuriyan, J.]]
+[[Category: Limnander, A.]]
+[[Category: Pelton, J G.]]
+[[Category: Roose, J P.]]
+[[Category: Vercoulen, Y.]]
+[[Category: Wemmer, D E.]]
+[[Category: Signaling protein]]