4bof: Difference between revisions
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{{STRUCTURE_4bof| PDB=4bof | SCENE= }} | |||
===Crystal structure of arginine deiminase from group A streptococcus=== | |||
{{ABSTRACT_PUBMED_23919999}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ARCA_STRPY ARCA_STRPY]] Antitumor protein. Has a powerful and dose-dependent inhibitory effect on antigen, superantigen, or mitogen-stimulated human peripheral blood mononuclear cell (PBMC) proliferation. It may inhibit cell proliferation by arresting cell cycle and inducing apoptosis (By similarity).[HAMAP-Rule:MF_00242] | |||
==About this Structure== | |||
[[4bof]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BOF OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023919999</ref><references group="xtra"/><references/> | |||
[[Category: Arginine deiminase]] | |||
[[Category: Streptococcus pyogenes]] | |||
[[Category: Aquilina, J A.]] | |||
[[Category: Batzloff, M R.]] | |||
[[Category: Casey, L.]] | |||
[[Category: Chhatwal, G S.]] | |||
[[Category: Ericsson, D J.]] | |||
[[Category: Henningham, A.]] | |||
[[Category: Jovcevski, B.]] | |||
[[Category: Kobe, B.]] | |||
[[Category: Langer, K.]] | |||
[[Category: Walker, M J.]] | |||
[[Category: Hydrolase]] | |||
[[Category: Vaccine]] | |||
Revision as of 08:29, 21 August 2013
Crystal structure of arginine deiminase from group A streptococcus
Template:ABSTRACT PUBMED 23919999
Function
[ARCA_STRPY] Antitumor protein. Has a powerful and dose-dependent inhibitory effect on antigen, superantigen, or mitogen-stimulated human peripheral blood mononuclear cell (PBMC) proliferation. It may inhibit cell proliferation by arresting cell cycle and inducing apoptosis (By similarity).[HAMAP-Rule:MF_00242]
About this Structure
4bof is a 8 chain structure with sequence from Streptococcus pyogenes. Full crystallographic information is available from OCA.
Reference
- Henningham A, Ericsson DJ, Langer K, Casey LW, Jovcevski B, Chhatwal GS, Aquilina JA, Batzloff MR, Kobe B, Walker MJ. Structure-informed design of an enzymatically inactive vaccine component for group A Streptococcus. MBio. 2013 Aug 6;4(4). pii: e00509-13. doi: 10.1128/mBio.00509-13. PMID:23919999 doi:10.1128/mBio.00509-13
