Adaptin: Difference between revisions
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<StructureSection load=' | <StructureSection load='2vgl' size='350' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[2vgl]])' scene=''> | ||
'''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a hetertetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals. | '''Adaptin''' (AP) are proteins which mediate the formation of vescicles by clathrin-coated pits. The AP complex is a hetertetramer composed of 2 large AP: AP-α or AP-γ and AP-β, a medium-size AP: AP-μ and small AP: AP-σ. AP complexes connect proteins and lipids to clathrin budding sites. There are different AP complexes in mammals. | ||
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'''AP-α + AP-β + AP-μ + AP-σ''' | '''AP-α + AP-β + AP-μ + AP-σ''' | ||
[[2vgl]] – rAPα + APβ + | [[2vgl]] – rAPα + APβ + APμ + APσ <br /> | ||
[[2jkr]], [[2jkt]] – mAPα + APβ + | [[2jkr]], [[2jkt]] – mAPα + APβ + APμ + APσ + CD4 peptide<br /> | ||
[[2xa7]] – rAPα + APβ + | [[2xa7]] – rAPα + APβ + APμ + APσ + cargo peptide<br /> | ||
'''AP-γ + AP-β + AP-μ + AP-σ''' | '''AP-γ + AP-β + AP-μ + AP-σ''' | ||
[[1w63]] – mAPγ + APβ + | [[1w63]] – mAPγ + APβ + APμ + APσ <br /> | ||
[[4hmy]] – mAPγ + APβ + | [[4hmy]] – mAPγ + APβ + APμ + APσ + ADP-ribosylation factor<br /> | ||
