4gid: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{STRUCTURE_4gid| PDB=4gid | SCENE= }} | {{STRUCTURE_4gid| PDB=4gid | SCENE= }} | ||
===Structure of beta-secretase complexed with inhibitor=== | ===Structure of beta-secretase complexed with inhibitor=== | ||
{{ABSTRACT_PUBMED_22954357}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4gid]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GID OCA]. | [[4gid]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GID OCA]. | ||
==See Also== | |||
*[[Beta secretase|Beta secretase]] | |||
==Reference== | |||
<ref group="xtra">PMID:022954357</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
[[Category: Anderson, D.]] | [[Category: Anderson, D.]] | ||
