4j8c: Difference between revisions
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{{STRUCTURE_4j8c| PDB=4j8c | SCENE= }} | {{STRUCTURE_4j8c| PDB=4j8c | SCENE= }} | ||
===Crystal structure of the dimerization domain of Hsc70-interacting protein=== | ===Crystal structure of the dimerization domain of Hsc70-interacting protein=== | ||
{{ABSTRACT_PUBMED_23812373}} | |||
==Function== | ==Function== | ||
| Line 7: | Line 8: | ||
==About this Structure== | ==About this Structure== | ||
[[4j8c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8C OCA]. | [[4j8c]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J8C OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023812373</ref><references group="xtra"/><references/> | |||
[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
[[Category: Bracher, A.]] | [[Category: Bracher, A.]] | ||
Revision as of 05:34, 28 August 2013
Crystal structure of the dimerization domain of Hsc70-interacting protein
Template:ABSTRACT PUBMED 23812373
Function
[F10A1_RAT] One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins.
About this Structure
4j8c is a 2 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
- Li Z, Hartl FU, Bracher A. Structure and function of Hip, an attenuator of the Hsp70 chaperone cycle. Nat Struct Mol Biol. 2013 Aug;20(8):929-35. doi: 10.1038/nsmb.2608. Epub 2013 Jun, 30. PMID:23812373 doi:10.1038/nsmb.2608
