4ekd: Difference between revisions
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{{STRUCTURE_4ekd| PDB=4ekd | SCENE= }} | {{STRUCTURE_4ekd| PDB=4ekd | SCENE= }} | ||
===Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)=== | ===Structure of human regulator of G protein signaling 2 (RGS2) in complex with murine Galpha-q(R183C)=== | ||
{{ABSTRACT_PUBMED_23434405}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/GNAQ_MOUSE GNAQ_MOUSE]] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Regulates B-cell selection and survival and is required to prevent B-cell-dependent autoimmunity. Regulates chemotaxis of BM-derived neutrophils and dendritic cells (in vitro).<ref>PMID:17938235</ref> <ref>PMID:20624888</ref> [[http://www.uniprot.org/uniprot/RGS2_HUMAN RGS2_HUMAN]] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. May play a role in leukemogenesis. Plays a role in negative feedback control pathway for adenylyl cyclase signaling. Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein.<ref>PMID:11278586</ref> <ref>PMID:17901199</ref> <ref>PMID:7643615</ref> <ref>PMID:19736320</ref> | |||
==About this Structure== | ==About this Structure== | ||
[[4ekd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKD OCA]. | [[4ekd]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4EKD OCA]. | ||
==Reference== | |||
<ref group="xtra">PMID:023434405</ref><references group="xtra"/><references/> | |||
[[Category: Heterotrimeric G-protein GTPase]] | [[Category: Heterotrimeric G-protein GTPase]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
