4i91: Difference between revisions
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{{STRUCTURE_4i91| PDB=4i91 | SCENE= }} | {{STRUCTURE_4i91| PDB=4i91 | SCENE= }} | ||
===Crystal Structure of Cytochrome P450 2B6 (Y226H/K262R) in complex with alpha-Pinene.=== | ===Crystal Structure of Cytochrome P450 2B6 (Y226H/K262R) in complex with alpha-Pinene.=== | ||
{{ABSTRACT_PUBMED_23786449}} | |||
==Function== | ==Function== | ||
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==About this Structure== | ==About this Structure== | ||
[[4i91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I91 OCA]. | [[4i91]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I91 OCA]. | ||
==See Also== | |||
*[[Cytochrome P450|Cytochrome P450]] | |||
==Reference== | ==Reference== | ||
<references group="xtra"/><references/> | <ref group="xtra">PMID:023786449</ref><references group="xtra"/><references/> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Halpert, J R.]] | [[Category: Halpert, J R.]] | ||
Revision as of 05:56, 28 August 2013
Crystal Structure of Cytochrome P450 2B6 (Y226H/K262R) in complex with alpha-Pinene.
Template:ABSTRACT PUBMED 23786449
Function
[CP2B6_HUMAN] Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,4-cineole 2-exo-monooxygenase.[1]
About this Structure
4i91 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See Also
Reference
- Wilderman PR, Shah MB, Jang HH, Stout CD, Halpert JR. Structural and Thermodynamic Basis of (+)-alpha-Pinene Binding to Human Cytochrome P450 2B6. J Am Chem Soc. 2013 Jul 17;135(28):10433-40. doi: 10.1021/ja403042k. Epub 2013, Jul 3. PMID:23786449 doi:10.1021/ja403042k
- ↑ Miyazawa M, Shindo M, Shimada T. Roles of cytochrome P450 3A enzymes in the 2-hydroxylation of 1,4-cineole, a monoterpene cyclic ether, by rat and human liver microsomes. Xenobiotica. 2001 Oct;31(10):713-23. PMID:11695850 doi:10.1080/00498250110065595
