2lxp: Difference between revisions

Line 1:

~~'''Unreleased~~ structure~~'''~~

===NMR structure of two domains in ubiquitin ligase gp78, RING and G2BR, bound to its conjugating enzyme Ube2g===

The ~~entry 2lxp~~ is ~~ON HOLD~~ ~~until Paper Publication~~

==Function==

[[http://www.uniprot.org/uniprot/UB2G2_HUMAN UB2G2_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).<ref>PMID:20061386</ref> <ref>PMID:22607976</ref> [[http://www.uniprot.org/uniprot/AMFR_HUMAN AMFR_HUMAN]] E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.<ref>PMID:10456327</ref> <ref>PMID:11724934</ref> <ref>PMID:16168377</ref> <ref>PMID:19103148</ref>

~~Authors~~: ~~Das, R~~.~~, Linag, Y~~.~~, Mariano, J~~.~~, Li, J~~.~~, Huang, T~~.~~, King, A~~.~~, Weissman, A~~.~~, Ji, X~~.~~, Byrd, R~~.

==About this Structure==

[[2lxp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXP OCA].

~~Description~~: ~~NMR structure of two domains in ubiquitin~~ ligase ~~gp78~~, ~~RING and G2BR~~, ~~bound to its conjugating enzyme Ube2g~~

==Reference==

[[Category: Homo sapiens]]

[[Category: Ochroconis lascauxensis]]

[[Category: Ubiquitin--protein ligase]]

[[Category: Byrd, R.]]

[[Category: Das, R.]]

[[Category: Huang, T.]]

[[Category: Ji, X.]]

[[Category: King, A.]]

[[Category: Li, J.]]

[[Category: Linag, Y.]]

[[Category: Mariano, J.]]

[[Category: Weissman, A.]]

[[Category: Ligase]]

[[Category: Ring domain]]

[[Category: Ubiquitin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_2lxp|  PDB=2lxp  |  SCENE=  }}
+===NMR structure of two domains in ubiquitin ligase gp78, RING and G2BR, bound to its conjugating enzyme Ube2g===
+{{ABSTRACT_PUBMED_23942235}}
-The entry 2lxp is ON HOLD  until Paper Publication
+==Function==
+[[http://www.uniprot.org/uniprot/UB2G2_HUMAN UB2G2_HUMAN]] Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Involved in endoplasmic reticulum-associated degradation (ERAD).<ref>PMID:20061386</ref> <ref>PMID:22607976</ref>  [[http://www.uniprot.org/uniprot/AMFR_HUMAN AMFR_HUMAN]] E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D, CYP3A4, CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also acts as a scaffold protein to assemble a complex that couples ubiquitination, retranslocation and deglycosylation. Mediates tumor invasion and metastasis as a receptor for the GPI/autocrine motility factor.<ref>PMID:10456327</ref> <ref>PMID:11724934</ref> <ref>PMID:16168377</ref> <ref>PMID:19103148</ref>
-Authors: Das, R., Linag, Y., Mariano, J., Li, J., Huang, T., King, A., Weissman, A., Ji, X., Byrd, R.
+==About this Structure==
+[[2lxp]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LXP OCA].
-Description: NMR structure of two domains in ubiquitin ligase gp78, RING and G2BR, bound to its conjugating enzyme Ube2g
+==Reference==
+<ref group="xtra">PMID:023942235</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: Ochroconis lascauxensis]]
+[[Category: Ubiquitin--protein ligase]]
+[[Category: Byrd, R.]]
+[[Category: Das, R.]]
+[[Category: Huang, T.]]
+[[Category: Ji, X.]]
+[[Category: King, A.]]
+[[Category: Li, J.]]
+[[Category: Linag, Y.]]
+[[Category: Mariano, J.]]
+[[Category: Weissman, A.]]
+[[Category: Ligase]]
+[[Category: Ring domain]]
+[[Category: Ubiquitin]]