4bxo: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Architecture and DNA recognition elements of the Fanconi anemia FANCM- FAAP24 complex===

The entry ~~4bxo is ON HOLD until Paper Publication~~

==Disease==

[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.

~~Authors~~: ~~Coulthard~~, R., ~~Deans, A~~.~~, Swuec, P~~.~~, Bowles, M~~.~~, Purkiss, A~~.~~, Costa, A~~., ~~West, S~~., ~~McDonald, N~~.

==Function==

[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8] [[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN]] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.

~~Description~~: ~~Architecture and DNA recognition elements of the Fanconi anemia FANCM~~-~~FAAP24~~ complex

==About this Structure==

[[4bxo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BXO OCA].

==Reference==

[[Category: Homo sapiens]]

[[Category: RNA helicase]]

[[Category: Bowles, M.]]

[[Category: Costa, A.]]

[[Category: Coulthard, R.]]

[[Category: Deans, A.]]

[[Category: McDonald, N.]]

[[Category: Purkiss, A.]]

[[Category: Swuec, P.]]

[[Category: West, S.]]

[[Category: Dna binding]]

[[Category: Hydrolase-dna complex]]

[[Category: Pseudo-nuclease]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4bxo|  PDB=4bxo  |  SCENE=  }}
+===Architecture and DNA recognition elements of the Fanconi anemia FANCM- FAAP24 complex===
+{{ABSTRACT_PUBMED_23932590}}
-The entry 4bxo is ON HOLD  until Paper Publication
+==Disease==
+[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] Fanconi anemia. The disease is caused by mutations affecting the gene represented in this entry.
-Authors: Coulthard, R., Deans, A., Swuec, P., Bowles, M., Purkiss, A., Costa, A., West, S., McDonald, N.
+==Function==
+[[http://www.uniprot.org/uniprot/FANCM_HUMAN FANCM_HUMAN]] ATPase required for FANCD2 ubiquitination, a key reaction in DNA repair. Binds to ssDNA but not to dsDNA. Recruited to forks stalled by DNA interstrand cross-links, and required for cellular resistance to such lesions.<ref>PMID:16116422</ref> <ref>PMID:16116434</ref> [REFERENCE:7][REFERENCE:8] [[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN]] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
-Description: Architecture and DNA recognition elements of the Fanconi anemia FANCM-FAAP24 complex
+==About this Structure==
+[[4bxo]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BXO OCA].
+==Reference==
+<ref group="xtra">PMID:023932590</ref><references group="xtra"/><references/>
+[[Category: Homo sapiens]]
+[[Category: RNA helicase]]
+[[Category: Bowles, M.]]
+[[Category: Costa, A.]]
+[[Category: Coulthard, R.]]
+[[Category: Deans, A.]]
+[[Category: McDonald, N.]]
+[[Category: Purkiss, A.]]
+[[Category: Swuec, P.]]
+[[Category: West, S.]]
+[[Category: Dna binding]]
+[[Category: Hydrolase-dna complex]]
+[[Category: Pseudo-nuclease]]