4lxm: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

===Crystal Structure of Human Beta Secretase in Complex with compound 12a===

~~The entry 4lxm~~ is ~~ON HOLD~~

==Function==

[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>

~~Authors~~: ~~Rondeau, J~~.M.~~, Bourgier, E~~.

==About this Structure==

[[4lxm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXM OCA].

~~Description~~: ~~Crystal~~ Structure ~~of Human Beta Secretase in Complex with compound 12a~~

==Reference==

[[Category: Memapsin 2]]

[[Category: Ochroconis lascauxensis]]

[[Category: Bourgier, E.]]

[[Category: Rondeau, J M.]]

[[Category: Aspartyl protease]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Membrane]]

[[Category: Structure-based drug design]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+{{STRUCTURE_4lxm|  PDB=4lxm  |  SCENE=  }}
+===Crystal Structure of Human Beta Secretase in Complex with compound 12a===
+{{ABSTRACT_PUBMED_22380629}}
-The entry 4lxm is ON HOLD
+==Function==
+[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref>
-Authors: Rondeau, J.M., Bourgier, E.
+==About this Structure==
+[[4lxm]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Ochroconis_lascauxensis Ochroconis lascauxensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4LXM OCA].
-Description: Crystal Structure of Human Beta Secretase in Complex with compound 12a
+==Reference==
+<ref group="xtra">PMID:022380629</ref><references group="xtra"/><references/>
+[[Category: Memapsin 2]]
+[[Category: Ochroconis lascauxensis]]
+[[Category: Bourgier, E.]]
+[[Category: Rondeau, J M.]]
+[[Category: Aspartyl protease]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Membrane]]
+[[Category: Structure-based drug design]]