4buj: Difference between revisions

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'''Unreleased structure'''
{{Large structure}}
{{STRUCTURE_4buj|  PDB=4buj  |  SCENE=  }}
===Crystal structure of the S. cerevisiae Ski2-3-8 complex===
{{ABSTRACT_PUBMED_23953113}}


The entry 4buj is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/SKI2_YEAST SKI2_YEAST]] RNA helicase component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon.<ref>PMID:8321235</ref> <ref>PMID:363683</ref> <ref>PMID:6371496</ref> <ref>PMID:7739552</ref> <ref>PMID:7739557</ref> <ref>PMID:9482746</ref> <ref>PMID:10611222</ref> <ref>PMID:10744028</ref> <ref>PMID:10922069</ref> <ref>PMID:11532933</ref> <ref>PMID:11720286</ref> <ref>PMID:12769863</ref> <ref>PMID:14671320</ref>  [[http://www.uniprot.org/uniprot/SKI8_YEAST SKI8_YEAST]] Involved in double-strand break (DSB) formation during meiotic recombination through stabilization of SPO11 association with meiotic chromosome and helping SPO11 to recruit other DSB proteins like REC102 and REC104 to meiotic chromosomes. Also component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for controlling the propagation of M double-stranded RNA (dsRNA) and thus for preventing virus-induced cytopathology.<ref>PMID:6371496</ref> <ref>PMID:3029964</ref> <ref>PMID:7739557</ref> <ref>PMID:9258672</ref> <ref>PMID:9482746</ref> <ref>PMID:10744028</ref> <ref>PMID:11532933</ref> <ref>PMID:11720286</ref> <ref>PMID:14671320</ref> <ref>PMID:15044957</ref> <ref>PMID:14992724</ref> <ref>PMID:16816949</ref>  [[http://www.uniprot.org/uniprot/SKI3_YEAST SKI3_YEAST]] Component of the SKI complex involved in 3'-mRNA degradation pathway. Represses dsRNA virus propagation by specifically blocking translation of viral mRNAs, perhaps recognizing the absence of CAP or poly(A). Essential for cell growth only in the presence of M1 replicon.<ref>PMID:363683</ref> <ref>PMID:6371496</ref> <ref>PMID:7739552</ref> <ref>PMID:7739557</ref> <ref>PMID:9482746</ref> <ref>PMID:10744028</ref> <ref>PMID:11532933</ref> <ref>PMID:11720286</ref> <ref>PMID:14671320</ref>  


Authors: Halbach, F., Reichelt, P., Rode, M., Conti, E.
==About this Structure==
[[4buj]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_s288c Saccharomyces cerevisiae s288c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4BUJ OCA].  


Description: Crystal structure of the S. cerevisiae Ski2-3-8 complex
==Reference==
<ref group="xtra">PMID:023953113</ref><references group="xtra"/><references/>
[[Category: RNA helicase]]
[[Category: Saccharomyces cerevisiae s288c]]
[[Category: Conti, E.]]
[[Category: Halbach, F.]]
[[Category: Reichelt, P.]]
[[Category: Rode, M.]]
[[Category: Dexh box helicase]]
[[Category: Hydrolase]]
[[Category: Protein complex]]
[[Category: Rna degradation]]
[[Category: Tpr]]