4gse: Difference between revisions

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'''Unreleased structure'''
{{STRUCTURE_4gse|  PDB=4gse  |  SCENE=  }}
===Structure analysis of cysteine-free insulin degrading enzyme with BDM-44619, 4-methyl-N-({1-[(2S)-1-(naphthalen-2-yl)-4-nitroso-4-oxobutan-2-yl]-1H- 1,2,3-Triazol-4-yl}methyl)benzamide===


The entry 4gse is ON HOLD until Paper Publication
==Function==
[[http://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN]] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>  


Authors: Guo, Q., Deprez-Poulain, R., Deprez, B., Tang, W.J.
==About this Structure==
[[4gse]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GSE OCA].  


Description: Structure analysis of cysteine-free insulin degrading enzyme with BDM-44619, 4-methyl-N-({1-[(2S)-1-(naphthalen-2-yl)-4-nitroso-4-oxobutan-2-yl]-1H-1,2,3-Triazol-4-yl}methyl)benzamide
==Reference==
<references group="xtra"/><references/>
[[Category: Homo sapiens]]
[[Category: Insulysin]]
[[Category: Deprez, B.]]
[[Category: Deprez-Poulain, R.]]
[[Category: Guo, Q.]]
[[Category: Tang, W J.]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Insulin degrading enzyme]]
Retrieved from "https://proteopedia.org/4gse"