3k74: Difference between revisions
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{{STRUCTURE_3k74| PDB=3k74 | SCENE= }} | {{STRUCTURE_3k74| PDB=3k74 | SCENE= }} | ||
===Disruption of protein dynamics by an allosteric effector antibody=== | ===Disruption of protein dynamics by an allosteric effector antibody=== | ||
{{ABSTRACT_PUBMED_21238460}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI]] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | |||
==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
<ref group="xtra">PMID:021238460</ref><references group="xtra"/> | <ref group="xtra">PMID:021238460</ref><references group="xtra"/><references/> | ||
[[Category: Dihydrofolate reductase]] | [[Category: Dihydrofolate reductase]] | ||
[[Category: Escherichia coli k-12]] | [[Category: Escherichia coli k-12]] | ||
Revision as of 08:45, 4 September 2013
Disruption of protein dynamics by an allosteric effector antibody
Template:ABSTRACT PUBMED 21238460
Function
[DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
About this Structure
3k74 is a 2 chain structure with sequence from Escherichia coli k-12 and Lama glama. Full crystallographic information is available from OCA.
See Also
Reference
- Oyen D, Srinivasan V, Steyaert J, Barlow JN. Constraining enzyme conformational change by an antibody leads to hyperbolic inhibition. J Mol Biol. 2011 Mar 18;407(1):138-48. Epub 2011 Jan 14. PMID:21238460 doi:10.1016/j.jmb.2011.01.017
