3u6a: Difference between revisions
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{{STRUCTURE_3u6a| PDB=3u6a | SCENE= }} | {{STRUCTURE_3u6a| PDB=3u6a | SCENE= }} | ||
===Rational Design and Synthesis of Aminopiperazinones as Beta Secretase (BACE) Inhibitors=== | ===Rational Design and Synthesis of Aminopiperazinones as Beta Secretase (BACE) Inhibitors=== | ||
{{ABSTRACT_PUBMED_22071305}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/BACE1_HUMAN BACE1_HUMAN]] Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.<ref>PMID:10677483</ref> <ref>PMID:20354142</ref> | |||
==About this Structure== | ==About this Structure== | ||
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==See Also== | ==See Also== | ||
*[[Beta secretase|Beta secretase]] | *[[Beta secretase|Beta secretase]] | ||
==Reference== | |||
<ref group="xtra">PMID:022071305</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Memapsin 2]] | [[Category: Memapsin 2]] | ||
