4g56: Difference between revisions

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===Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis===

==Function==

[[http://www.uniprot.org/uniprot/ANM5_XENLA ANM5_XENLA]] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins; such methylation being required for the assembly and biogenesis of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation (By similarity). Methylates the arginine in the motif G-R-G-X-G in its substrates histone H2A, H2AFX and H4, producing both monomethylated and symmetrically dimethylated 'Arg-3'. Methylates nucleoplasmin at 'Arg-192', producing both monomethylated and symmetrically dimethylated 'Arg-192'. Involved in the DNA replication checkpoint. Promotes entry into mitosis by promoting the proteasomal degradation of wee2-a. [[http://www.uniprot.org/uniprot/MEP50_XENLA MEP50_XENLA]] Non-catalytic component of the 20S prmt5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. Required for normal prmt5 methyltransferase activity.

==About this Structure==

[[4g56]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G56 OCA].

==Reference==

[[Category: Xenopus laevis]]

[[Category: Almo, S C.]]

[[Category: Bonanno, J.]]

[[Category: Ho, M.]]

[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]

[[Category: Shechter, D.]]

[[Category: Wilczek, C.]]

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 ===Crystal Structure of full length PRMT5/MEP50 complexes from Xenopus laevis===
 {{ABSTRACT_PUBMED_23451136}}
+==Function==
+[[http://www.uniprot.org/uniprot/ANM5_XENLA ANM5_XENLA]] Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins; such methylation being required for the assembly and biogenesis of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation (By similarity). Methylates the arginine in the motif G-R-G-X-G in its substrates histone H2A, H2AFX and H4, producing both monomethylated and symmetrically dimethylated 'Arg-3'. Methylates nucleoplasmin at 'Arg-192', producing both monomethylated and symmetrically dimethylated 'Arg-192'. Involved in the DNA replication checkpoint. Promotes entry into mitosis by promoting the proteasomal degradation of wee2-a. [[http://www.uniprot.org/uniprot/MEP50_XENLA MEP50_XENLA]] Non-catalytic component of the 20S prmt5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins and histones. Required for normal prmt5 methyltransferase activity.
 ==About this Structure==
 [[4g56]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4G56 OCA].
+==Reference==
+<ref group="xtra">PMID:023451136</ref><references group="xtra"/><references/>
 [[Category: Xenopus laevis]]
 [[Category: Almo, S C.]]
 [[Category: Bonanno, J.]]
 [[Category: Ho, M.]]
+[[Category: NYSGRC, New York Structural Genomics Research Consortium.]]
 [[Category: Shechter, D.]]
 [[Category: Wilczek, C.]]