4jvm: Difference between revisions
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{{STRUCTURE_4jvm| PDB=4jvm | SCENE= }} | |||
===Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and brominated flame retardant TBBPA (tetrabromobisphenol A)=== | |||
{{ABSTRACT_PUBMED_23959441}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/ST1E1_HUMAN ST1E1_HUMAN]] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.<ref>PMID:11884392</ref> | |||
==About this Structure== | |||
[[4jvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JVM OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023959441</ref><references group="xtra"/><references/> | |||
[[Category: Estrone sulfotransferase]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Birnbaum, L S.]] | |||
[[Category: Gosavi, R A.]] | |||
[[Category: Knudsen, G A.]] | |||
[[Category: Pedersen, L C.]] | |||
[[Category: Cytosolic sulfotransferase]] | |||
[[Category: Transferase]] | |||
Revision as of 10:47, 4 September 2013
Crystal structure of human estrogen sulfotransferase (SULT1E1) in complex with inactive cofactor PAP and brominated flame retardant TBBPA (tetrabromobisphenol A)
Template:ABSTRACT PUBMED 23959441
Function
[ST1E1_HUMAN] Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of estradiol and estrone. May play a role in the regulation of estrogen receptor activity by metabolizing free estradiol. Maximally sulfates beta-estradiol and estrone at concentrations of 20 nM. Also sulfates dehydroepiandrosterone, pregnenolone, ethinylestradiol, equalenin, diethylstilbesterol and 1-naphthol, at significantly higher concentrations; however, cortisol, testosterone and dopamine are not sulfated.[1]
About this Structure
4jvm is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Gosavi RA, Knudsen GA, Birnbaum LS, Pedersen LC. Mimicking of Estradiol Binding by Flame Retardants and Their Metabolites: A Crystallographic Analysis. Environ Health Perspect. 2013 Aug 19. PMID:23959441 doi:10.1289/ehp.1306902
- ↑ Pedersen LC, Petrotchenko E, Shevtsov S, Negishi M. Crystal structure of the human estrogen sulfotransferase-PAPS complex: evidence for catalytic role of Ser137 in the sulfuryl transfer reaction. J Biol Chem. 2002 May 17;277(20):17928-32. Epub 2002 Mar 7. PMID:11884392 doi:https://dx.doi.org/10.1074/jbc.M111651200
