4gi4: Difference between revisions
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{{STRUCTURE_4gi4| PDB=4gi4 | SCENE= }} | |||
===tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor=== | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TGT_ZYMMO TGT_ZYMMO]] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168] | |||
==About this Structure== | |||
[[4gi4]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Zymomonas_mobilis_subsp._mobilis_zm4_=_atcc_31821 Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4GI4 OCA]. | |||
[[Category: Zymomonas mobilis subsp. mobilis zm4 = atcc 31821]] | |||
[[Category: Immekus, F.]] | |||
[[Category: Klebe, G.]] | |||
[[Category: Biosynthesis]] | |||
[[Category: Queuosine]] | |||
[[Category: Tim barrel glycosyltransferase]] | |||
[[Category: Transferase-transferase inhibitor complex]] | |||
[[Category: Trna]] | |||
[[Category: Trna processing]] | |||
Revision as of 10:56, 4 September 2013
tRNA Guanine Transglycosylase in complex with disubstituted lin-benzoguanine inhibitor
Function
[TGT_ZYMMO] Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).[HAMAP-Rule:MF_00168]
About this Structure
4gi4 is a 1 chain structure with sequence from Zymomonas mobilis subsp. mobilis zm4 = atcc 31821. Full crystallographic information is available from OCA.
