4m4e: Difference between revisions
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{{STRUCTURE_4m4e| PDB=4m4e | SCENE= }} | |||
===TRAF domain of human TRAF4=== | |||
{{ABSTRACT_PUBMED_23982741}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/TRAF4_HUMAN TRAF4_HUMAN]] Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract (By similarity). Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions.<ref>PMID:12023963</ref> <ref>PMID:12801526</ref> <ref>PMID:16052631</ref> <ref>PMID:16157600</ref> <ref>PMID:18953416</ref> <ref>PMID:19937093</ref> | |||
==About this Structure== | |||
[[4m4e]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4M4E OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023982741</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Ding, W.]] | |||
[[Category: Liu, Z J.]] | |||
[[Category: Niu, F.]] | |||
[[Category: Ouyang, S.]] | |||
[[Category: Ru, H.]] | |||
[[Category: Adaptor protein]] | |||
[[Category: Regular protein]] | |||
[[Category: Signaling protein]] | |||
[[Category: Traf domain]] | |||
[[Category: Traf4]] | |||