2m9m: Difference between revisions
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{{STRUCTURE_2m9m| PDB=2m9m | SCENE= }} | |||
===Solution Structure of ERCC4 domain of human FAAP24=== | |||
{{ABSTRACT_PUBMED_23999858}} | |||
==Function== | |||
[[http://www.uniprot.org/uniprot/FAP24_HUMAN FAP24_HUMAN]] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA. | |||
==About this Structure== | |||
[[2m9m]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M9M OCA]. | |||
==Reference== | |||
<ref group="xtra">PMID:023999858</ref><references group="xtra"/><references/> | |||
[[Category: Homo sapiens]] | |||
[[Category: Gong, W.]] | |||
[[Category: Han, X.]] | |||
[[Category: Shi, C.]] | |||
[[Category: Tian, C.]] | |||
[[Category: Wu, F.]] | |||
[[Category: Dna binding protein]] | |||
[[Category: Ercc4 domain]] | |||
[[Category: Faap24]] | |||
[[Category: Fanconi anemia]] | |||
Revision as of 04:09, 20 September 2013
Solution Structure of ERCC4 domain of human FAAP24
Template:ABSTRACT PUBMED 23999858
Function
[FAP24_HUMAN] Plays a role in DNA repair through recruitment of the FA core complex to damaged DNA. Regulates FANCD2 monoubiquitination upon DNA damage. Induces chromosomal instability as well as hypersensitivity to DNA cross-linking agents, when repressed. Targets FANCM/FAAP24 complex to the DNA, preferentially to single strand DNA.
About this Structure
2m9m is a 1 chain structure with sequence from Homo sapiens. Full experimental information is available from OCA.
Reference
- Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res. 2013 Sep 3. doi: 10.1038/cr.2013.124. PMID:23999858 doi:10.1038/cr.2013.124
